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The Ospreys, fresh from their safe passage into the EDF Energy Cup semi-finals last weekend, will look to build momentum to a patchy season against managerless Ulster.
Lyn Jones’ EDF energy cup semi-finalists lost to Gloucester at Kingsholm in the last round but backed by a vocal Liberty Stadium and an in-form Gavin Henson, the Welsh region should be eyeing up maximum points in order to make the quarter-finals.
Ulster have lost both Heineken Cup clashes this season but caretaker coach Steve Williams will hope the 1999 winners can salvage their European campaign with an upset in Swansea.
But Williams will need Ireland quartet Tommy Bowe, Andrew Trimble, Paddy Wallace and Isaac Boss to be firing on all cylinders to have any chance of picking up points.