Sale Sharks go to Calvisano knowing they need a bonus point win to stay in the hunt for qualification from Pool 3.
Having kept their Heineken Cup hopes alive last month with a 12-6 win over Stade Francais at Edgeley Park, it is vital that the Sharks capitalize with a big win over the Italian side.
Sale beat Calvisano 67-11 in Round 2 and will be hoping for a repeat performance at the Centre Sportive San Michele.

Calvisano are without a point this season and are without a win in the competition since 2003.