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The Dragons are out of the competition but will play a huge part on the final placings in Pool One.
Paul Turner’s men entertain Perpignan at Rodney Parade and an upset could cost the French outfit a place in the quarter-finals.
Perpignan got a bonus-point last weekend versus Treviso but need another big win to achieve a runners-up slot if London Irish win in Italy.
But defeat could signal the end of Perpignan’s Heineken Cup campaign so expect a fast start.