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The match of the weekend sees the star-studded Ospreys take on the challenge of Pool 2 leaders Gloucester at the Liberty Stadium.
Lyn Jones’ men beat Ulster home and away in Rounds Three and Four to keep their destiny in their own hands.
However, the Guinness Premiership leaders are the only team in the Heineken Cup to boast a 100% winning record.
Gloucester took the points in a tight 26-18 encounter at Kingsholm in November and this should be another tough contest.